New Study: Cannabidiol Can Help Cigarette Smokers Quit
Courtesy of The Joint Blog
A new placebo-controlled study published in last month’s issue of the journal http://cdn.theweedblog.com/wp-content/uploads/cannabidiol-cbd-cannabis-marijuana.jpgAddictive Behaviors has found that cannabidiol – a cannabis compound – can significantly reduce the number of cigarettes consumed by those wishing to quit.
For the study, participants were given cannabidiol (CBD) through an inhaler – the CBD was derived entirely from the actual cannabis plant. Participants were separated into two groups, one which received the inhaler containing CBD, and one which contained a placebo.
Researchers found that those in the placebo group showed no difference in the amount that they smoked. However, those in the CBD group smoked, on average, 40% less after just a 1-week period.
“We found that CBD seems to reduce the salience of cues. It also can reduce anxiety and may affect a memory process called ‘reconsolidation,’ which is where when a memory of the reward of smoking is re-activated by seeing someone smoking, it is rendered vulnerable to destruction”, says Dr. Celia Morgan, co-author of the study. “CBD might mean these positive smoking memories are gradually erased,”
The role of the endocannabinoid system in nicotine addiction is being increasingly acknowledged. We conducted a pilot, randomised double blind placebo controlled study set out to assess the impact of the ad-hoc use of cannabidiol (CBD) in smokers who wished to stop smoking. 24 smokers were randomised to receive an inhaler of CBD (n = 12) or placebo (n = 12) for one week, they were instructed to use the inhaler when they felt the urge to smoke. Over the treatment week, placebo treated smokers showed no differences in number of cigarettes smoked. In contrast, those treated with CBD significantly reduced the number of cigarettes smoked by ~ 40% during treatment. Results also indicated some maintenance of this effect at follow-up. These preliminary data, combined with the strong preclinical rationale for use of this compound, suggest CBD to be a potential treatment for nicotine addiction that warrants further exploration.
Nicotine; Smoking cessation; Addiction; Cannabidiol; Endocannabinoids