Cannabinoids inhibit glioma cell invasion in brain cancer studies
Researchers in Spain publish juicy studies such as this one: Cannabinoids, the active components of Cannabis sativa L. and their derivatives, inhibit tumor growth in laboratory animals by inducing apoptosis of tumor cells and impairing tumor angiogenesis.
It has also been reported that these compounds inhibit tumor cell spreading, but the molecular targets of this cannabinoid action remain elusive. Here, we evaluated the effect of cannabinoids on matrix metalloproteinase (MMP) expression and its effect on tumor cell invasion. Local administration of Delta(9)-tetrahydrocannabinol (THC), the major active ingredient of cannabis, down-regulated MMP-2 expression in gliomas generated in mice, as determined by Western blot, immunofluorescence, and real-time quantitative PCR analyses. This cannabinoid-induced inhibition of MMP-2 expression in gliomas (a) was MMP-2-selective, as levels of other MMP family members were unaffected; (b) was mimicked by JWH-133, a CB(2) cannabinoid receptor-selective agonist that is devoid of psychoactive side effects; (c) was abrogated by fumonisin B1, a selective inhibitor of ceramide biosynthesis; and (d) was also evident in two patients with recurrent glioblastoma multiforme. THC inhibited MMP-2 expression and cell invasion in cultured glioma cells. Manipulation of MMP-2 expression by RNA interference and cDNA overexpression experiments proved that down-regulation of this MMP plays a critical role in THC-mediated inhibition of cell invasion. Cannabinoid-induced inhibition of MMP-2 expression and cell invasion was prevented by blocking ceramide biosynthesis and by knocking-down the expression of the stress protein p8. As MMP-2 up-regulation is associated with high progression and poor prognosis of gliomas and many other tumors, MMP-2 down-regulation constitutes a new hallmark of cannabinoid antitumoral activity. www.ncbi.nlm.nih.gov/pubmed/18339876
Allegheny General Hospital in Pittsburgh has been FDA approved for the use of an experimental drug called 5-aminolevunilic acid (5-ALA) that is used to illuminate and locate brain tumors using UV light.
Will the FDA allow Allegheny General doctors to use cannabinoids to treat invading glioma cells on patients in Pittsburgh Pennsylvania? Probably not!
Pennsylvanians are still without a medical marijuana bill. And although Pittsburgh is a major medical research center, most Pittsburghers are reluctant to discuss the subject of HB 1393.
And many of the cannabis products available for testing in the United States are not available for testing on humans. Synthetic Marijuana
If you are interested in more studies about cannabis and glioma here are some good ones.
Targeting astrocytomas and invading immune cells with cannabinoids: a promising therapeutic avenue.
Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.
Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?