Cannabidiol For Neurodegenerative Disorders- Important New Clinical Applications For This Phytocannabinoid

(Source:The British Pharmacological Society ) Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties . CBD acts in some cases as agent in these cases: anti-inflammatory anticonvulsant anti-oxidant anti-emetic anxiolytic …

(Source:The British Pharmacological Society )

Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties . CBD acts in some cases as agent in these cases:

anti-inflammatory
anticonvulsant
anti-oxidant
anti-emetic
anxiolytic
antipsychotic

Therefore a potential medicine for the treatment of :

neuroinflammation
epilepsy
oxidative injury
vomiting
nausea
anxiety
schizophrenia
The neuroprotective potential of CBD, based on the combination of its anti-inflammatory and anti-oxidant properties, is of particular interest and is presently under intense preclinical research in numerous neurodegenerative disorders. In fact, CBD combined with Δ(9)-tetrahydrocannabinol is already under clinical evaluation in patients with Huntington’s disease to determine its potential as a disease-modifying therapy. The neuroprotective properties of CBD do not appear to be exerted by the activation of key targets within the endocannabinoid system for plant-derived cannabinoids like Δ(9)-tetrahydrocannabinol, i.e. CB(1) and CB(2) receptors, as CBD has negligible activity at these cannabinoid receptors, although certain activity at the CB(2) receptor has been documented in specific pathological conditions (i.e. damage of immature brain).

Within the endocannabinoid system, CBD has been shown to have an inhibitory effect on the inactivation of endocannabinoids (i.e. inhibition of FAAH enzyme), thereby enhancing the action of these endogenous molecules on cannabinoid receptors, which is also noted in certain pathological conditions. CBD acts not only through the endocannabinoid system, but also causes direct or indirect activation of metabotropic receptors for serotonin or adenosine, and can target nuclear receptors of the PPAR family and also ion channels.

 

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