What are Flavonoids?
From the article:
Cannflavins A, B and C
They have anti-inflammatory activity due to the fact that they inhibit the prostaglandins’ inflammatory pathway. This mechanism is shared with other terpenoids which are present in the Cannabis plant, providing a better synergy and anti-inflammatory effect to that coming from cannabinoids.
Vitexin and Isovitexin
Therapeutic applicability for gout, inhibiting the thyroid peroxidase.
It seems to have an antidepressant effect. A rich diet in kaempferol may reduce the risk of cancer and some coronary diseases. Although some are opposed, other theories state that Cannabis seems to have certain antidepressant effects in some cases, so it could be that there is a synergistic effect coming from the combination of kaempferol and cannabinoids.
It has shown to decrease the secondary effects of ciclosporin A, an immunosuppressive administered during organ transplants to avoid the rejection of the transplanted organ. It has also been proven that apigenin is one of the few substances capable of stimulating the monoamine transporter, altering the neurotransmitter levels. It has recently become clear that apigenin acts as an anxiolytic and sedative on the GABA receptors. The fact that this effect is shared by the cannabinoids bring us to a possible synergy between axiolict and sedative effects of cannabinoids.
It inhibits viral enzymes and it can have antiviral effects. It also inhibits the production of prostaglandins, acting as an anti-inflammatory. The quercitin can have synergy with the cannabinoids too by increasing the anti-inflammatory effects. A recent study suggests quercitin may have therapeutic applicability in treating fibromyalgia, due to its anti-inflammatory effects. As has been shown, Cannabis has therapeutic effects in managing fibromyalgia, which could prove the synergy between quercitin and Cannabis. Similarly, quercitin inhibits the monoamine oxidase enzyme (MAO), which is involved in the metabolism of neurotransmitters and pharmaceuticals. This factor should be to be taken into account, with regards to possible interactions with particular pharmaceuticals.
Luteonin and Orientin (luteonin glucoside)
Both luteonin and orientin have shown to have pharmacologic effects as antioxidants, anti-inflammatories, antibiotics and as agents against cancer in preclinical studies. They can also have synergy with cannabinoids.